Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor

Dietary restriction (DR) is a metabolic intervention that extends the lifespan of multiple species, including yeast, flies, nematodes, rodents, and, arguably, rhesus monkeys and humans. Hallmarks of lifelong DR are reductions in body size, fecundity, and fat accumulation, as well as slower developme...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Bar, Daniel Z., Charar, Chayki, Dorfman, Jehudith, Yadid, Tam, Tafforeau, Lionel, Lafontaine, Denis L. J., Gruenbaum, Yosef
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2016
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PNAS Plus
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987808/
https://ncbi.nlm.nih.gov/pubmed/27457958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512156113
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