Global transcriptional changes caused by an EDMD mutation correlate to tissue specific disease phenotypes in C. elegans

There are numerous heritable diseases associated with mutations in the LMNA gene. Most of these laminopathic diseases, including several muscular dystrophies, are autosomal dominant and have tissue-specific phenotypes. Our previous studies have shown that the globally expressed Emery-Dreifuss muscul...

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Podrobná bibliografie
Vydáno v:Nucleus
Hlavní autoři: Zuela, Noam, Dorfman, Jehudith, Gruenbaum, Yosef
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5287205/
https://ncbi.nlm.nih.gov/pubmed/27673727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2016.1238999
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