Global transcriptional changes caused by an EDMD mutation correlate to tissue specific disease phenotypes in C. elegans

There are numerous heritable diseases associated with mutations in the LMNA gene. Most of these laminopathic diseases, including several muscular dystrophies, are autosomal dominant and have tissue-specific phenotypes. Our previous studies have shown that the globally expressed Emery-Dreifuss muscul...

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Bibliographic Details
Published in:Nucleus
Main Authors: Zuela, Noam, Dorfman, Jehudith, Gruenbaum, Yosef
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2016
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5287205/
https://ncbi.nlm.nih.gov/pubmed/27673727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2016.1238999
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