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Global transcriptional changes caused by an EDMD mutation correlate to tissue specific disease phenotypes in C. elegans

There are numerous heritable diseases associated with mutations in the LMNA gene. Most of these laminopathic diseases, including several muscular dystrophies, are autosomal dominant and have tissue-specific phenotypes. Our previous studies have shown that the globally expressed Emery-Dreifuss muscul...

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Bibliografski detalji
Izdano u:Nucleus
Glavni autori: Zuela, Noam, Dorfman, Jehudith, Gruenbaum, Yosef
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5287205/
https://ncbi.nlm.nih.gov/pubmed/27673727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2016.1238999
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