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Reversal of age-dependent nuclear morphology by inhibition of prenylation does not affect lifespan in Caenorhabditis elegans

Fibroblasts derived from Hutchinson-Gilford progeria syndrome (HGPS) patients and dermal cells derived from healthy old humans in culture display age-dependent progressive changes in nuclear architecture due to accumulation of farnesylated lamin A. Treating human HGPS cells or mice expressing farnes...

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Autores principales: Bar, Daniel Z, Gruenbaum, Yosef
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3027053/
https://ncbi.nlm.nih.gov/pubmed/21327093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/nucl.1.6.13223
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