Supraphysiologic levels of the AML1-ETO isoform AE9a are essential for transformation

Chromosomal translocation 8;21 is found in 40% of the FAB M2 subtype of acute myeloid leukemia (AML). The resultant in-frame fusion protein AML1-ETO (AE) acts as an initiating oncogene for leukemia development. AE immortalizes human CD34(+) cord blood cells in long-term culture. We assessed the tran...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Link, Kevin A., Lin, Shan, Shrestha, Mahesh, Bowman, Melissa, Wunderlich, Mark, Bloomfield, Clara D., Huang, Gang, Mulloy, James C.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987773/
https://ncbi.nlm.nih.gov/pubmed/27457952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524225113
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