Structural Investigation of Park’s Nucleotide on Bacterial Translocase MraY: Discovery of Unexpected MraY Inhibitors

Systematic structural modifications of the muramic acid, peptide, and nucleotide moieties of Park’s nucleotide were performed to investigate the substrate specificity of B. subtilis MraY (MraY(BS)). It was found that the simplest analogue of Park’s nucleotide only bearing the first two amino acids,...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Chen, Kuo-Ting, Chen, Po-Ting, Lin, Cheng-Kun, Huang, Lin-Ya, Hu, Chia-Ming, Chang, Yi-Fan, Hsu, Hua-Ting, Cheng, Ting-Jen R., Wu, Ying-Ta, Cheng, Wei-Chieh
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987650/
https://ncbi.nlm.nih.gov/pubmed/27531195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31579
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