Structural Investigation of Park’s Nucleotide on Bacterial Translocase MraY: Discovery of Unexpected MraY Inhibitors

Systematic structural modifications of the muramic acid, peptide, and nucleotide moieties of Park’s nucleotide were performed to investigate the substrate specificity of B. subtilis MraY (MraY(BS)). It was found that the simplest analogue of Park’s nucleotide only bearing the first two amino acids,...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Chen, Kuo-Ting, Chen, Po-Ting, Lin, Cheng-Kun, Huang, Lin-Ya, Hu, Chia-Ming, Chang, Yi-Fan, Hsu, Hua-Ting, Cheng, Ting-Jen R., Wu, Ying-Ta, Cheng, Wei-Chieh
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987650/
https://ncbi.nlm.nih.gov/pubmed/27531195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31579
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