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Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay
Many gene expression factors contain repetitive phosphorylation sites for single kinases, but the functional significance is poorly understood. Here we present evidence for hyperphosphorylation as a mechanism allowing UPF1, the central factor in nonsense-mediated decay (NMD), to increasingly attract...
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| Published in: | Nat Commun |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4987530/ https://ncbi.nlm.nih.gov/pubmed/27511142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12434 |
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