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Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay
Many gene expression factors contain repetitive phosphorylation sites for single kinases, but the functional significance is poorly understood. Here we present evidence for hyperphosphorylation as a mechanism allowing UPF1, the central factor in nonsense-mediated decay (NMD), to increasingly attract...
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Publicado no: | Nat Commun |
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Main Authors: | , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4987530/ https://ncbi.nlm.nih.gov/pubmed/27511142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12434 |
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