Target discrimination in nonsense-mediated mRNA decay requires Upf1 ATPase activity

RNA quality control pathways get rid of faulty RNAs and therefore must be able to discriminate these RNAs from those that are normal. Here we present evidence that the ATPase cycle of the SF1 Helicase Upf1 is required for mRNA discrimination during Nonsense-Mediated Decay (NMD). Mutations affecting...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Lee, Suzanne R., Pratt, Gabriel, Martinez, Fernando, Yeo, Gene W., Lykke-Andersen, Jens
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673969/
https://ncbi.nlm.nih.gov/pubmed/26253027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.06.036
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