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Novel anticancer agents based on targeting the trimer interface of the PRL phosphatase

PRL oncoproteins are phosphatases overexpressed in numerous types of human cancer. Elevated levels of PRL associate with metastasis and poor clinical outcomes. In principle, PRL phosphatases offer appealing therapeutic targets, but they remain underexplored due to the lack of specific chemical probe...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Bai, Yunpeng, Yu, Zhi-Hong, Liu, Sijiu, Zhang, Lujuan, Zhang, Ruo-Yu, Zeng, Li-Fan, Zhang, Sheng, Zhang, Zhong-Yin
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987244/
https://ncbi.nlm.nih.gov/pubmed/27325652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2323
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