Genetic and Environmental Risk for Chronic Pain and the Contribution of Risk Variants for Major Depressive Disorder: A Family-Based Mixed-Model Analysis

BACKGROUND: Chronic pain is highly prevalent and a significant source of disability, yet its genetic and environmental risk factors are poorly understood. Its relationship with major depressive disorder (MDD) is of particular importance. We sought to test the contribution of genetic factors and shar...

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Détails bibliographiques
Publié dans:PLoS Med
Auteurs principaux: McIntosh, Andrew M., Hall, Lynsey S., Zeng, Yanni, Adams, Mark J., Gibson, Jude, Wigmore, Eleanor, Hagenaars, Saskia P., Davies, Gail, Fernandez-Pujals, Ana Maria, Campbell, Archie I., Clarke, Toni-Kim, Hayward, Caroline, Haley, Chris S., Porteous, David J., Deary, Ian J., Smith, Daniel J., Nicholl, Barbara I., Hinds, David A., Jones, Amy V., Scollen, Serena, Meng, Weihua, Smith, Blair H., Hocking, Lynne J.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987025/
https://ncbi.nlm.nih.gov/pubmed/27529168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002090
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