Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer

BACKGROUND: Inherited mutations in DNA-repair genes such as BRCA2 are associated with increased risks of lethal prostate cancer. Although the prevalence of germline mutations in DNA-repair genes among men with localized prostate cancer who are unselected for family predisposition is insufficient to...

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Published in:N Engl J Med
Main Authors: Pritchard, C.C., Mateo, J., Walsh, M.F., De Sarkar, N., Abida, W., Beltran, H., Garofalo, A., Gulati, R., Carreira, S., Eeles, R., Elemento, O., Rubin, M.A., Robinson, D., Lonigro, R., Hussain, M., Chinnaiyan, A., Vinson, J., Filipenko, J., Garraway, L., Taplin, M-E., AlDubayan, S., Han, G.C., Beightol, M., Morrissey, C., Nghiem, B., Cheng, H.H., Montgomery, B., Walsh, T., Casadei, S., Berger, M., Zhang, L., Zehir, A., Vijai, J., Scher, H.I., Sawyers, C., Schultz, N., Kantoff, P.W., Solit, D., Robson, M., Van Allen, E.M., Offit, K., de Bono, J., Nelson, P.S.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4986616/
https://ncbi.nlm.nih.gov/pubmed/27433846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1603144
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