Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator

Medullary thymic epithelial cells (mTECs) expressing autoimmune regulator (Aire) are critical for preventing the onset of autoimmunity. However, the differentiation program of Aire-expressing mTECs (Aire(+) mTECs) is unclear. Here, we describe novel embryonic precursors of Aire(+) mTECs. We found th...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Akiyama, Nobuko, Takizawa, Nobukazu, Miyauchi, Maki, Yanai, Hiromi, Tateishi, Ryosuke, Shinzawa, Miho, Yoshinaga, Riko, Kurihara, Masaaki, Demizu, Yosuke, Yasuda, Hisataka, Yagi, Shintaro, Wu, Guoying, Matsumoto, Mitsuru, Sakamoto, Reiko, Yoshida, Nobuaki, Penninger, Josef M., Kobayashi, Yasuhiro, Inoue, Jun-ichiro, Akiyama, Taishin
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4986530/
https://ncbi.nlm.nih.gov/pubmed/27401343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151780
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