Poly-dipeptides encoded by the C9ORF72 repeats block global protein translation

The expansion of the GGGGCC hexanucleotide repeat in the non-coding region of the Chromosome 9 open-reading frame 72 (C9orf72) gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). This genetic alteration leads to the accumulation of five typ...

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Publicado en:Hum Mol Genet
Main Authors: Kanekura, Kohsuke, Yagi, Takuya, Cammack, Alexander J., Mahadevan, Jana, Kuroda, Masahiko, Harms, Matthew B., Miller, Timothy M., Urano, Fumihiko
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4986334/
https://ncbi.nlm.nih.gov/pubmed/26931465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw052
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