S-nitrosylation of tissue-type plasminogen activator confers vasodilatory and antiplatelet properties on the enzyme.

Tissue-type plasminogen activator (t-PA) reacts upon exposure to endothelium-derived relaxing factor (EDRF) by way of the enzyme's single free sulfhydryl (Cys-83) to form a stable S-nitrosothiol protein adduct. S-nitrosylation endows t-PA with potent vasodilatory and antiplatelet properties tha...

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Détails bibliographiques
Auteurs principaux: Stamler, J S, Simon, D I, Jaraki, O, Osborne, J A, Francis, S, Mullins, M, Singel, D, Loscalzo, J
Format: Artigo
Langue:Inglês
Publié: 1992
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC49861/
https://ncbi.nlm.nih.gov/pubmed/1325644
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