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S-nitrosylation of tissue-type plasminogen activator confers vasodilatory and antiplatelet properties on the enzyme.

Tissue-type plasminogen activator (t-PA) reacts upon exposure to endothelium-derived relaxing factor (EDRF) by way of the enzyme's single free sulfhydryl (Cys-83) to form a stable S-nitrosothiol protein adduct. S-nitrosylation endows t-PA with potent vasodilatory and antiplatelet properties that are...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Stamler, J S, Simon, D I, Jaraki, O, Osborne, J A, Francis, S, Mullins, M, Singel, D, Loscalzo, J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49861/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1325644/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.17.8087
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