S-nitrosylation of tissue-type plasminogen activator confers vasodilatory and antiplatelet properties on the enzyme.

Tissue-type plasminogen activator (t-PA) reacts upon exposure to endothelium-derived relaxing factor (EDRF) by way of the enzyme's single free sulfhydryl (Cys-83) to form a stable S-nitrosothiol protein adduct. S-nitrosylation endows t-PA with potent vasodilatory and antiplatelet properties that are...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Stamler, J S, Simon, D I, Jaraki, O, Osborne, J A, Francis, S, Mullins, M, Singel, D, Loscalzo, J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49861/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1325644/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.17.8087
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