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Epigenetic Repeat-Induced Gene Silencing in the Chromosomal and Extrachromosomal Contexts in Human Cells

A plasmid bearing both a replication initiation region and a matrix attachment region is spontaneously amplified in transfected mammalian cells and generates plasmid repeats in the extrachromosomal double minutes (DMs) or the chromosomal homogeneously staining region (HSR). Generally, the repeat seq...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Mitsuda, Sho-hei, Shimizu, Noriaki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985131/
https://ncbi.nlm.nih.gov/pubmed/27525955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161288
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