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Epigenetic Repeat-Induced Gene Silencing in the Chromosomal and Extrachromosomal Contexts in Human Cells

A plasmid bearing both a replication initiation region and a matrix attachment region is spontaneously amplified in transfected mammalian cells and generates plasmid repeats in the extrachromosomal double minutes (DMs) or the chromosomal homogeneously staining region (HSR). Generally, the repeat seq...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Mitsuda, Sho-hei, Shimizu, Noriaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985131/
https://ncbi.nlm.nih.gov/pubmed/27525955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161288
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