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Replacing Uridine with 2-Thiouridine Enhances the Rate and Fidelity of Nonenzymatic RNA Primer Extension
[Image: see text] The nonenzymatic replication of RNA oligonucleotides is thought to have played a key role in the origin of life prior to the evolution of ribozyme-catalyzed RNA replication. Although the copying of oligo-C templates by 2-methylimidazole-activated G monomers can be quite efficient,...
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| I publikationen: | J Am Chem Soc |
|---|---|
| Huvudupphovsmän: | , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Chemical
Society
2015
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| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4985000/ https://ncbi.nlm.nih.gov/pubmed/25654265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b00445 |
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