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Generation of Functional RNAs from Inactive Oligonucleotide Complexes by Non-enzymatic Primer Extension

[Image: see text] The earliest genomic RNAs had to be short enough for efficient replication, while simultaneously serving as unfolded templates and effective ribozymes. A partial solution to this paradox may lie in the fact that many functional RNAs can self-assemble from multiple fragments. Theref...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Adamala, Katarzyna, Engelhart, Aaron E., Szostak, Jack W.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984999/
https://ncbi.nlm.nih.gov/pubmed/25521912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja511564d
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