Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs

[Image: see text] Optimization of pyridine-based noncatalytic site integrase inhibitors (NCINIs) based on compound 2 has led to the discovery of molecules capable of inhibiting virus harboring N124 variants of HIV integrase (IN) while maintaining minimal contribution of enterohepatic recirculation t...

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Bibliografiska uppgifter
I publikationen:ACS Med Chem Lett
Huvudupphovsmän: Fader, Lee D., Bailey, Murray, Beaulieu, Eric, Bilodeau, François, Bonneau, Pierre, Bousquet, Yves, Carson, Rebekah J., Chabot, Catherine, Coulombe, René, Duan, Jianmin, Fenwick, Craig, Garneau, Michel, Halmos, Ted, Jakalian, Araz, James, Clint, Kawai, Stephen H., Landry, Serge, LaPlante, Steven R., Mason, Stephen W., Morin, Sebastien, Rioux, Nathalie, Simoneau, Bruno, Surprenant, Simon, Thavonekham, Bounkham, Thibeault, Carl, Trinh, Thao, Tsantrizos, Youla, Tsoung, Jennifer, Yoakim, Christiane, Wernic, Dominik
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2016
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983734/
https://ncbi.nlm.nih.gov/pubmed/27563405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00194
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