Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability

A major obstacle hindering the development of effective immunity against viral infections, their associated disease, and certain cancers is their inherent genomic instability. Accumulation of mutations can alter processing and presentation of antigens recognized by antibodies and T cells that can le...

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Veröffentlicht in:J Leukoc Biol
Hauptverfasser: Spear, Timothy T., Riley, Timothy P., Lyons, Gretchen E., Callender, Glenda G., Roszkowski, Jeffrey J., Wang, Yuan, Simms, Patricia E., Scurti, Gina M., Foley, Kendra C., Murray, David C., Hellman, Lance M., McMahan, Rachel H., Iwashima, Makio, Garrett-Mayer, Elizabeth, Rosen, Hugo R., Baker, Brian M., Nishimura, Michael I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Leukocyte Biology 2016
Schlagworte:
Receptors, Signal Transduction, & Genes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4982612/
https://ncbi.nlm.nih.gov/pubmed/26921345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.2A1215-561R
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