Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells

The use of T cell receptor (TCR) gene-modified T cells in adoptive cell transfer has had promising clinical success, but often, simple preclinical evaluation does not necessarily accurately predict treatment efficacy or safety. Preclinical studies generally evaluate one or a limited number of type 1...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Spear, Timothy T., Wang, Yuan, Smith, Thomas W., Simms, Patricia E., Garrett-Mayer, Elizabeth, Hellman, Lance M., Baker, Brian M., Nishimura, Michael I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6079370/
https://ncbi.nlm.nih.gov/pubmed/29503203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.01.015
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