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ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing

The processing of MHC class I antigenic precursor peptides by the endoplasmic reticulum aminopeptidase 1 (ERAP1) and ERAP2 is an important event in the cell biology of antigen presentation. To date, the molecular context by which the ERAP enzymes trim precursor peptides, and how ERAPs shape peptide...

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書目詳細資料
發表在:Sci Rep
Main Authors: Chen, Hanna, Li, Lenong, Weimershaus, Mirjana, Evnouchidou, Irini, van Endert, Peter, Bouvier, Marlene
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981824/
https://ncbi.nlm.nih.gov/pubmed/27514473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28902
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