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ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing

The processing of MHC class I antigenic precursor peptides by the endoplasmic reticulum aminopeptidase 1 (ERAP1) and ERAP2 is an important event in the cell biology of antigen presentation. To date, the molecular context by which the ERAP enzymes trim precursor peptides, and how ERAPs shape peptide...

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Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Chen, Hanna, Li, Lenong, Weimershaus, Mirjana, Evnouchidou, Irini, van Endert, Peter, Bouvier, Marlene
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981824/
https://ncbi.nlm.nih.gov/pubmed/27514473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28902
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