The Internal Sequence of the Peptide-Substrate Determines Its N-Terminus Trimming by ERAP1

BACKGROUND: Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims N-terminally extended antigenic peptide precursors down to mature antigenic peptides for presentation by major histocompatibility complex (MHC) class I molecules. ERAP1 has unique properties for an aminopeptidase being able to trim pep...

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Detalhes bibliográficos
Main Authors: Evnouchidou, Irini, Momburg, Frank, Papakyriakou, Athanasios, Chroni, Angeliki, Leondiadis, Leondios, Chang, Shih-Chung, Goldberg, Alfred L., Stratikos, Efstratios
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573961/
https://ncbi.nlm.nih.gov/pubmed/18987748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003658
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