The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy

Carbonic anhydrase IX (CAIX) is a tumor-specific protein that is upregulated during hypoxic conditions where it is involved in maintaining the pH balance. CAIX causes extracellular acidification, thereby limiting the uptake of weak basic chemotherapeutic agents, such as doxorubicin, and decreasing i...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: van Kuijk, Simon J. A., Gieling, Roben G., Niemans, Raymon, Lieuwes, Natasja G., Biemans, Rianne, Telfer, Brian A., Haenen, Guido R. M. M., Yaromina, Ala, Lambin, Philippe, Dubois, Ludwig J., Williams, Kaye J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981362/
https://ncbi.nlm.nih.gov/pubmed/27513947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161040
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