In vivo optical imaging of MMP2 immuno protein antibody: tumor uptake is associated with MMP2 activity

Matrix metalloproteinase-2 (MMP2) is important in tumorigenesis, angiogenesis and tumor invasion. In this study, we investigated if the Cy5-tagged small immuno protein targeting the catalytic domain of human MMP2 (aMMP2-SIP) detects MMP2 in tumors non-invasively. For this purpose, we generated MMP2...

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Udgivet i:Sci Rep
Main Authors: Panth, Kranthi Marella, van den Beucken, Twan, Biemans, Rianne, Lieuwes, Natasja G., Weber, Marcel, Losen, Mario, Yaromina, Ala, Dubois, Ludwig J., Lambin, Philippe
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770595/
https://ncbi.nlm.nih.gov/pubmed/26923459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22198
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