Mitochondrial Dysfunction Inhibits Hypoxia-Induced HIF-1α Stabilization and Expression of Its Downstream Targets

mtDNA variations often result in bioenergetic dysfunction inducing a metabolic switch toward glycolysis resulting in an unbalanced pH homeostasis. In hypoxic cells, expression of the tumor-associated carbonic anhydrase IX (CAIX) is enhanced to maintain cellular pH homeostasis. We hypothesized that c...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: van Gisbergen, Marike W., Offermans, Kelly, Voets, An M., Lieuwes, Natasja G., Biemans, Rianne, Hoffmann, Roland F., Dubois, Ludwig J., Lambin, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7248342/
https://ncbi.nlm.nih.gov/pubmed/32509579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00770
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