The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy

Carbonic anhydrase IX (CAIX) is a tumor-specific protein that is upregulated during hypoxic conditions where it is involved in maintaining the pH balance. CAIX causes extracellular acidification, thereby limiting the uptake of weak basic chemotherapeutic agents, such as doxorubicin, and decreasing i...

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Vydáno v:PLoS One
Hlavní autoři: van Kuijk, Simon J. A., Gieling, Roben G., Niemans, Raymon, Lieuwes, Natasja G., Biemans, Rianne, Telfer, Brian A., Haenen, Guido R. M. M., Yaromina, Ala, Lambin, Philippe, Dubois, Ludwig J., Williams, Kaye J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981362/
https://ncbi.nlm.nih.gov/pubmed/27513947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161040
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