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Wild type huntingtin toxicity in yeast: Implications for the role of amyloid cross-seeding in polyQ diseases

Proteins with expanded polyglutamine (polyQ) regions are prone to form amyloids, which can cause diseases in humans and toxicity in yeast. Recently, we showed that in yeast non-toxic amyloids of Q-rich proteins can induce aggregation and toxicity of wild type huntingtin (Htt) with a short non-pathog...

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Detalhes bibliográficos
Publicado no:Prion
Main Authors: Alexandrov, A. I., Serpionov, G. V., Kushnirov, V. V., Ter-Avanesyan, M. D.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981198/
https://ncbi.nlm.nih.gov/pubmed/27220690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336896.2016.1176659
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