Llwytho...
A protein polymerization cascade mediates toxicity of non-pathological human huntingtin in yeast
Several neurodegenerative amyloidoses, including Huntington disease, are caused by expansion of polyglutamine (polyQ) stretches in otherwise unrelated proteins. In a yeast model, an N-terminal fragment of mutant huntingtin with a stretch of 103 glutamine residues aggregates and causes toxicity, whil...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Sci Rep |
|---|---|
| Prif Awduron: | , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Nature Publishing Group
2015
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4682096/ https://ncbi.nlm.nih.gov/pubmed/26673834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18407 |
| Tagiau: |
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