A carregar...
A protein polymerization cascade mediates toxicity of non-pathological human huntingtin in yeast
Several neurodegenerative amyloidoses, including Huntington disease, are caused by expansion of polyglutamine (polyQ) stretches in otherwise unrelated proteins. In a yeast model, an N-terminal fragment of mutant huntingtin with a stretch of 103 glutamine residues aggregates and causes toxicity, whil...
Na minha lista:
| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4682096/ https://ncbi.nlm.nih.gov/pubmed/26673834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18407 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|