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Transthyretin Suppresses Amyloid-β secretion by Interfering with Processing of The Amyloid-β Precursor Protein
In Alzheimer’s disease (AD) most hippocampal and cortical neurons show increased staining with anti-transthyretin (TTR) antibodies. Genetically programmed over-expression of wild type human TTR suppressed the neuropathologic and behavioral abnormalities in APP23 AD model mice and TTR-Aβ complexes ha...
Gardado en:
| Publicado en: | J Alzheimers Dis |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4980917/ https://ncbi.nlm.nih.gov/pubmed/27079720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-160033 |
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