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Transthyretin Suppresses Amyloid-β secretion by Interfering with Processing of The Amyloid-β Precursor Protein

In Alzheimer’s disease (AD) most hippocampal and cortical neurons show increased staining with anti-transthyretin (TTR) antibodies. Genetically programmed over-expression of wild type human TTR suppressed the neuropathologic and behavioral abnormalities in APP23 AD model mice and TTR-Aβ complexes ha...

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Bibliografiske detaljer
Udgivet i:J Alzheimers Dis
Main Authors: Li, Xinyi, Song, Yuanli, Sanders, Charles R., Buxbaum, Joel N.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980917/
https://ncbi.nlm.nih.gov/pubmed/27079720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-160033
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