Expansion and activation of CD103(+) dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic PD-L1 and BRAF inhibition

Large numbers of melanoma lesions develop resistance to targeted inhibition of mutant BRAF or fail to respond to checkpoint blockade. We explored whether modulation of intratumoral antigen presenting cells (APCs) could increase responses to these therapies. Using mouse melanoma models, we found that...

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Veröffentlicht in:Immunity
Hauptverfasser: Salmon, Hélène, Idoyaga, Juliana, Rahman, Adeeb, Leboeuf, Marylène, Remark, Romain, Jordan, Stefan, Casanova-Acebes, Maria, Khudoynazarova, Makhzuna, Agudo, Judith, Tung, Navpreet, Chakarov, Svetoslav, Rivera, Christina, Hogstad, Brandon, Bosenberg, Marcus, Hashimoto, Daigo, Gnjatic, Sacha, Bhardwaj, Nina, Palucka, Anna Karolina, Brown, Brian D., Brody, Joshua, Ginhoux, Florent, Merad, Miriam
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980762/
https://ncbi.nlm.nih.gov/pubmed/27096321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.03.012
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