Expansion and activation of CD103(+) dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic PD-L1 and BRAF inhibition

Large numbers of melanoma lesions develop resistance to targeted inhibition of mutant BRAF or fail to respond to checkpoint blockade. We explored whether modulation of intratumoral antigen presenting cells (APCs) could increase responses to these therapies. Using mouse melanoma models, we found that...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Salmon, Hélène, Idoyaga, Juliana, Rahman, Adeeb, Leboeuf, Marylène, Remark, Romain, Jordan, Stefan, Casanova-Acebes, Maria, Khudoynazarova, Makhzuna, Agudo, Judith, Tung, Navpreet, Chakarov, Svetoslav, Rivera, Christina, Hogstad, Brandon, Bosenberg, Marcus, Hashimoto, Daigo, Gnjatic, Sacha, Bhardwaj, Nina, Palucka, Anna Karolina, Brown, Brian D., Brody, Joshua, Ginhoux, Florent, Merad, Miriam
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980762/
https://ncbi.nlm.nih.gov/pubmed/27096321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.03.012
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