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The cell cycle inhibitor Cdkn1a regulates Langerhans cell radiation resistance and promotes T regulatory cell generation upon exposure to ionizing irradiation
Treatment with ionizing irradiation (IR) may lead to accumulation of tumor-infiltrating T regulatory (T(reg)) cells and subsequent tumor resistance to radiotherapy. Here we focused on the contribution of the epidermal mononuclear phagocytes, Langerhans cells (LCs), to this phenomenon because of thei...
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| Publicado no: | Nat Immunol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4620552/ https://ncbi.nlm.nih.gov/pubmed/26343536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3270 |
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