The cell cycle inhibitor Cdkn1a regulates Langerhans cell radiation resistance and promotes T regulatory cell generation upon exposure to ionizing irradiation

Treatment with ionizing irradiation (IR) may lead to accumulation of tumor-infiltrating T regulatory (T(reg)) cells and subsequent tumor resistance to radiotherapy. Here we focused on the contribution of the epidermal mononuclear phagocytes, Langerhans cells (LCs), to this phenomenon because of thei...

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Bibliographic Details
Published in:Nat Immunol
Main Authors: Price, Jeremy G., Idoyaga, Juliana, Salmon, Hélène, Hogstad, Brandon, Bigarella, Carolina L., Ghaffari, Saghi, Leboeuf, Marylene, Merad, Miriam
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620552/
https://ncbi.nlm.nih.gov/pubmed/26343536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3270
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