RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions

Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by granulomatous lesions containing pathological CD207(+) dendritic cells (DCs) with constitutively activated mitogen-activated protein kinase (MAPK) pathway signaling. Approximately 60% of LCH patients harbor som...

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Vydáno v:J Exp Med
Hlavní autoři: Hogstad, Brandon, Berres, Marie-Luise, Chakraborty, Rikhia, Tang, Jun, Bigenwald, Camille, Serasinghe, Madhavika, Lim, Karen Phaik Har, Lin, Howard, Man, Tsz-Kwong, Remark, Romain, Baxter, Samantha, Kana, Veronika, Jordan, Stefan, Karoulia, Zoi, Kwan, Wing-hong, Leboeuf, Marylene, Brandt, Elisa, Salmon, Helene, McClain, Kenneth, Poulikakos, Poulikos, Chipuk, Jerry, Mulder, Willem J.M., Allen, Carl E., Merad, Miriam
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2018
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748846/
https://ncbi.nlm.nih.gov/pubmed/29263218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161881
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