Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect

SAMHD1, a dNTP triphosphohydrolase, contributes to interferon signaling and restriction of retroviral replication. SAMHD1-mediated retroviral restriction is thought to result from the depletion of cellular dNTP pools, but it remains controversial whether the dNTPase activity of SAMHD1 is sufficient...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Bhattacharya, Akash, Wang, Zhonghua, White, Tommy, Buffone, Cindy, Nguyen, Laura A., Shepard, Caitlin N., Kim, Baek, Demeler, Borries, Diaz-Griffero, Felipe, Ivanov, Dmitri N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980677/
https://ncbi.nlm.nih.gov/pubmed/27511536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31353
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