Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth

A role for Hedgehog (Hh) signalling in the development of colorectal cancer (CRC) has been proposed. In CRC and other solid tumours, Hh ligands are upregulated; however, a specific Hh antagonist provided no benefit in a clinical trial. Here we use Hh reporter mice to show that downstream Hh activity...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Gerling, Marco, Büller, Nikè V. J. A., Kirn, Leonard M., Joost, Simon, Frings, Oliver, Englert, Benjamin, Bergström, Åsa, Kuiper, Raoul V., Blaas, Leander, Wielenga, Mattheus C. B., Almer, Sven, Kühl, Anja A., Fredlund, Erik, van den Brink, Gijs R., Toftgård, Rune
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980446/
https://ncbi.nlm.nih.gov/pubmed/27492255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12321
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