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Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
A role for Hedgehog (Hh) signalling in the development of colorectal cancer (CRC) has been proposed. In CRC and other solid tumours, Hh ligands are upregulated; however, a specific Hh antagonist provided no benefit in a clinical trial. Here we use Hh reporter mice to show that downstream Hh activity...
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Publicado no: | Nat Commun |
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Main Authors: | , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4980446/ https://ncbi.nlm.nih.gov/pubmed/27492255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12321 |
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