Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth

A role for Hedgehog (Hh) signalling in the development of colorectal cancer (CRC) has been proposed. In CRC and other solid tumours, Hh ligands are upregulated; however, a specific Hh antagonist provided no benefit in a clinical trial. Here we use Hh reporter mice to show that downstream Hh activity...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Gerling, Marco, Büller, Nikè V. J. A., Kirn, Leonard M., Joost, Simon, Frings, Oliver, Englert, Benjamin, Bergström, Åsa, Kuiper, Raoul V., Blaas, Leander, Wielenga, Mattheus C. B., Almer, Sven, Kühl, Anja A., Fredlund, Erik, van den Brink, Gijs R., Toftgård, Rune
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2016
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980446/
https://ncbi.nlm.nih.gov/pubmed/27492255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12321
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk