Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth

A role for Hedgehog (Hh) signalling in the development of colorectal cancer (CRC) has been proposed. In CRC and other solid tumours, Hh ligands are upregulated; however, a specific Hh antagonist provided no benefit in a clinical trial. Here we use Hh reporter mice to show that downstream Hh activity...

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Publié dans:Nat Commun
Auteurs principaux: Gerling, Marco, Büller, Nikè V. J. A., Kirn, Leonard M., Joost, Simon, Frings, Oliver, Englert, Benjamin, Bergström, Åsa, Kuiper, Raoul V., Blaas, Leander, Wielenga, Mattheus C. B., Almer, Sven, Kühl, Anja A., Fredlund, Erik, van den Brink, Gijs R., Toftgård, Rune
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980446/
https://ncbi.nlm.nih.gov/pubmed/27492255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12321
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