Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth

A role for Hedgehog (Hh) signalling in the development of colorectal cancer (CRC) has been proposed. In CRC and other solid tumours, Hh ligands are upregulated; however, a specific Hh antagonist provided no benefit in a clinical trial. Here we use Hh reporter mice to show that downstream Hh activity...

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Publicado en:Nat Commun
Autores principales: Gerling, Marco, Büller, Nikè V. J. A., Kirn, Leonard M., Joost, Simon, Frings, Oliver, Englert, Benjamin, Bergström, Åsa, Kuiper, Raoul V., Blaas, Leander, Wielenga, Mattheus C. B., Almer, Sven, Kühl, Anja A., Fredlund, Erik, van den Brink, Gijs R., Toftgård, Rune
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980446/
https://ncbi.nlm.nih.gov/pubmed/27492255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12321
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