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N-end rule pathway inhibition assists colon tumor regression via necroptosis
Recent study has shown that N-end rule pathway, an ubiquitin dependent proteolytic system, counteracts cell death by degrading many antisurvival protein fragments like BCL(xL), BRCA1, RIPK1, etc. Inhibition of the N-end rule pathway can lead to metabolic stabilization of proapoptotic protein fragmen...
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| Publicado no: | Mol Ther Oncolytics |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4980110/ https://ncbi.nlm.nih.gov/pubmed/27556106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mto.2016.20 |
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