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Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway
Multivalent binding allows high selectivity and affinity in a ligand–protein interaction. The N-end rule pathway is a ubiquitin (Ub)-dependent proteolytic system in which specific E3s, called N-recognins, mediate ubiquitylation through the recognition of types 1 and 2, destabilizing N-terminal resid...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2224166/ https://ncbi.nlm.nih.gov/pubmed/18162545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708465105 |
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