Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway

Multivalent binding allows high selectivity and affinity in a ligand–protein interaction. The N-end rule pathway is a ubiquitin (Ub)-dependent proteolytic system in which specific E3s, called N-recognins, mediate ubiquitylation through the recognition of types 1 and 2, destabilizing N-terminal resid...

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Detalles Bibliográficos
Main Authors: Lee, Min Jae, Pal, Krishnendu, Tasaki, Takafumi, Roy, Sayantani, Jiang, Yonghua, An, Jee Young, Banerjee, Rajkumar, Kwon, Yong Tae
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224166/
https://ncbi.nlm.nih.gov/pubmed/18162545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708465105
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