Pilot PET Study to Assess the Functional Interplay Between ABCB1 and ABCG2 at the Human Blood–Brain Barrier

ABCB1 and ABCG2 work together at the blood–brain barrier (BBB) to limit brain distribution of dual ABCB1/ABCG2 substrates. In this pilot study we used positron emission tomography (PET) to assess brain distribution of two model ABCB1/ABCG2 substrates ([(11)C]elacridar and [(11)C]tariquidar) in healt...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Bauer, M, Römermann, K, Karch, R, Wulkersdorfer, B, Stanek, J, Philippe, C, Maier‐Salamon, A, Haslacher, H, Jungbauer, C, Wadsak, W, Jäger, W, Löscher, W, Hacker, M, Zeitlinger, M, Langer, O
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Clinical Trial
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979595/
https://ncbi.nlm.nih.gov/pubmed/26940368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.362
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