Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold

Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum resident of the heat shock protein 90 kDa (Hsp90) family of molecular chaperones. Grp94 associates with many proteins involved in cell adhesion and signaling, including integrins, Toll-like receptors, immunoglobulins, and mutant myoci...

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Publicado en:J Med Chem
Autores principales: Crowley, Vincent M., Khandelwal, Anuj, Mishra, Sanket, Stothert, Andrew R., Huard, Dustin J. E., Zhao, Jinbo, Muth, Aaron, Duerfeldt, Adam S., Kizziah, James L., Lieberman, Raquel L., Dickey, Chad A., Blagg, Brian S. J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979570/
https://ncbi.nlm.nih.gov/pubmed/27003516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00085
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