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Second Generation Grp94-selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer

Glucose regulated protein 94 (Grp94) is the ER resident isoform of the 90 kDa heat shock protein family (Hsp90) and represents a promising therapeutic target for the treatment of many diseases. Modification of the cis-amide bioisostere to alter the angle between the resorcinol ring and the benzyl si...

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Publicado en:Chemistry
Main Authors: Crowley, Vincent M., Huard, Dustin J. E., Lieberman, Raquel L., Blagg, Brian S. J.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722212/
https://ncbi.nlm.nih.gov/pubmed/28857290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201703398
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