Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold

Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum resident of the heat shock protein 90 kDa (Hsp90) family of molecular chaperones. Grp94 associates with many proteins involved in cell adhesion and signaling, including integrins, Toll-like receptors, immunoglobulins, and mutant myoci...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Crowley, Vincent M., Khandelwal, Anuj, Mishra, Sanket, Stothert, Andrew R., Huard, Dustin J. E., Zhao, Jinbo, Muth, Aaron, Duerfeldt, Adam S., Kizziah, James L., Lieberman, Raquel L., Dickey, Chad A., Blagg, Brian S. J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979570/
https://ncbi.nlm.nih.gov/pubmed/27003516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00085
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